- Rocket Launcher
Successfully complete the game in under three hours. Then, begin another game from your saved game file to begin with the Rocket Launcher in your inventory.

- Alternate costumes
Successfully complete Jill Valentine's scenario with Barry Burton alive or Chris Redfield's scenario with Rebecca Chambers alive. Save the game, then load the cleared game file to begin with the Special Key in your inventory. Use it to unlock the closet in Mansion 1F to access the alternate costumes. Notice: The alternate costumes are different in Classic and Rebirth modes.

- Play as Albert Wesker in Multiplayer mode
Get a 'B' or greater rank in the Masters Of Knifing mini-game to unlock Albert Wesker in Multiplayer mode.

- Play as Barry Burton in Multiplayer mode
Successfully complete Rebirth mode with Jill to unlock Barry Burton in Multiplayer mode.

- Easy mode
At the main menu, keep pushed Right until the 'New Game' option turns green. Begin a game and double the normal amount of items, including ink ribbons and ammunition, will be available. Notice: This does not effect other items, such as health sprays or herbs.


Additionally, after selecting 'New Game', keep pushed Right on 'Rebirth Mode' until it turns green to play both Rebirth and Classic modes on the easy difficulty setting.

- Spitting zombie revenge in Rebirth mode
When a zombie begins spitting, blow into the microphone to send it back at them.

- Play as Enrico Marini in Multiplayer mode
Successfully complete all Co-Op levels in Multiplayer mode to unlock Enrico Marini in Multiplayer mode.

- Play as Kenneth J. Sullivan in Multiplayer mode
Successfully complete Classic mode with Chris to unlock Kenneth J. Sullivan in Multiplayer mode.

- Bonus animation
Let Jill idle until she does her hand-on-hip pose, then tap her on the chest or butt with the stylus to view a bonus animation.

- Masters Of Knifing mini-game
Successfully complete the game to unlock the Masters Of Knifing mini-game.

- Play as Rebecca Chambers in Multiplayer mode
Successfully complete Rebirth mode with Chris to unlock Rebecca Chambers in Multiplayer mode.

- Play as Forest Speyer in Multiplayer mode
Successfully complete Classic mode with Jill to unlock Forest Speyer in Multiplayer mode.

- Play as Richard Aiken in Multiplayer mode
Successfully complete all Versus mode levels in Multiplayer mode to unlock Richard Aiken in Multiplayer mode.