- Normal and mutated strains of Triti GUILT
There are two strains of Triti GUILT; both have almost the same way to cure it. For the normal type, use the healing touch then take out all the thorns. Then, scalpel as much as possible and remove the pieces. If you are quick enough, you can remove all the triangles in one shot. If any thorns remain, more triangles will appear. You will encounter the non-mutated version of this GUILT once. The mutated form is the same, except when you pull the thorns out they might release white gas. If they release gas, then you must use the drain. Because of the gas you will have to remove the Triti slower than before. Remove all of the thorns like before, and drain any gas that comes out. Then, cut out at least two or three pieces, depending how long it took to take out the thorns. With this form you need the healing touch to slow things down enough to drain gas. If you let gas wander around and do not drain it, it will make more Triti that you have to remove. Notice: If you allow the gas to float around or do not remove all the thorns, and your fighting the mutated form of Triti, turn off the game and rebegin. You must remove all the thorns before you can do anything. If you have a large body of Triti, then you will never be able to remove all the thorns, drain the gas, and cut out the pieces in time to remove them before the thorns grow back.

- Defusing the bomb
When you are defusing the bomb, take your time. After you are told to pull out the triggers, you do not have to worry about the water anymore. All you will have to do now is follow the wires coming out of the box that show you the temperature. After that, you must take your time. You have to cut red wires and if you touch the white you will lose. Once you cut all the red wires, you will get the operation successful message.

- Bonus X missions
Successfully complete the game to unlock the bonus X missions in Challenge mode. Completing each X mission unlocks the next mission in the series, in the following order:

X4	Tetarti
X2	Deftera
X6	Parakevi
X5	Pempti
X3	Triti
X1	Kyriaki
X7	Savato

- Better CPR
When giving CPR, put antibiotic gel on the blue bar before you begin pumping to decrease the time the patient spends flatlining by a lot.