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Overcomeing Vapor
Use the handclap whenever she is in her vapor state. If she gets dizzy, you can land some punches on her.
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Comic book locations
The comic books can be found at the following locations:
The following mission must be completed to collect the corresponding comic book:
| 10. Fire From The Sky | The Problem Is The Hulk |
| 13. This Is Only A Test... | We Can Use Their Tech |
| 12. Enclave's Ultimate Weapon | The Lesser Of Two Evils |
| 8. Blonsky... Broken... | Our Old Research Data mission |
| 4. Sonic Assault | Just Take Him Down mission |
| 6. Talbot The Madman | This Guy's Bad News mission |
| 5. Bye Bye Bi-Beast | A Mass Mind Control Device mission |
| 14. Betty's Peril | It's Time To End This |
| 1. Face Of The Monster | He Must Not Escape mission |
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| 2. Bruce And Goliath | The Enclave And Rick Jones mission |
| 11. The Lesser Of Two Evils | The Lesser Of Two Evils |
| 3. The Flop-tastic Four | A Friend Who Can Help mission |
| 7. Just A Hop, Skip And A Jump | Destruction In A Single Bound mission |
| 9. Turret Syndrome | The Problem Is The Hulk |
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| 15. Abomination Domination | We've Got The Antidote mission |
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Overcomeing Skull
Throw objects until his electrical blasts decreases. Quickly throw something on him or punch him a few times. Repeat this until he has been defeated.
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Overcomeing Ironclad
Pick up objects (cars works well), and jump away. Quickly turn, and target him. Throw objects in his face when he comes jumping. He has hard fists; after you hit him, quickly jump away.
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Easier fights
Try to take fights where you want, if possible. For example, lure both U-Foes and Enclave leaders to Central Park. There are streets with cars on every side, so you can easy smash a few cars or buildings to fill the Rage meter faster. When you jump on trees, the leaves fall, making it so you have excellent visibility on the battlefield. Use Rage attacks whenever you are full and have a clear shot.
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Overcomeing Vector
Throw projectiles at his shield. When he becomes dizzy, punch him several times until the shield begins again.
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Jump Challenge locations
The Jump Challenges can be found at the following locations:
| 10. Swiss Bank Tower | |
| 13. Time Warner Center | |
| 12. Carnegie Hall | |
| 8. The building north of the Reuters Building. It has a star-shaped top. The jump ring is horizontal; you must look up to find it. | |
| 4. Third building south of the Flatiron Building | |
| 6. Madison Square Garden | |
| 5. Beside the Empire State Building (fall into it) | |
| 14. Southeast of the Empire State University Subway | |
| 1. World Financial Center | |
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| 2. Behind the Woolworth Building | |
| 11. Citigroup Center | |
| 3. 20 Exchange Place | |
| 7. U.S. Trust Building | |
| 9. South of Time Square, near Jump Challenge #8, slightly further south between a skyscraper and a smaller building, down low. | |
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| 15. North central area of Central Park | |
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Bonus characters
Successfully complete the indicated task to unlock the corresponding character:
| Hulkbuster Iron Man | Have a saved game file from Iron Man. |
| Maestro | Destroy a building in each neighborhood. |
| Abomination | Overcome Abomination. |
| Bi-Beast | Overcome Bi-Beast. |
| Professor Hulk (Smart Hulk) | Successfully complete all jump challenges. |
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| Ironclad | Overcome the U-Foes, trick a U-Foe into KOing his teammate, and defeat Abomination. |
| Grey Hulk | Smash 10,000 objects. |
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| Savage Hulk | Acquire five comic book covers. |
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