- Alternate ending
Successfully complete the game twice to view an extra scene after the credits.

- New Game+ mode
Successfully complete the game to unlock New Game+ mode, which allows two cheats to be unlocked by spending BP.

- Alternate Lightning Set
To unlock the Lightning Custom and Blaze Edge, successfully complete the game thirty times. Successfully complete the game at least twice on the Easy, Normal, Hard, Deadly, and Genocide difficulties before the thirtieth playthrough. Notice: If you have already completed the game more than thirty times, you can still unlock the Lightning Custom and Blaze Edge as soon as you complete the game on the difficulty level that you have not yet completed twice. Enabling 'Activate Cheats' is acceptable.

- Special weapons
Successfully complete the indicated task to unlock the corresponding weapon for purchase:

Mk.46 Mod0	Successfully complete the game on the Normal difficulty.
Blaze Edge	Successfully complete the game and have at least seven stamps on the Square-Enix Member site.
M249	Successfully complete the game.
M240B	Successfully complete the game twice on the Hard difficulty.
Pile Bunker	Unlock and purchase all weapons and weapon parts in the game.

- Music files
Successfully complete the game twice on any difficulty to unlock the music files.

- Genocide mode
Successfully complete the game on the Deadly difficulty to unlock the Genocide difficulty.

- Watch damaged outfit
Successfully complete the game while wearing only one outfit from the first through the last episode.

- Extra DNA Boards
You will gain an extra DNA Board each time you complete the game, for a maximum of five boards.

- Video Log option
Successfully complete the game to unlock the 'Video Log' option, which allows you to view all of the videos.

- Easy Evolved DNA
While fighting Hyde Bohr (demi-human form) in Episode 6, let him kill Aya to trigger a short cutscene. After it ends, Aya will have assistance from Kyle, Gabriel, Thelonious, and Blank. Overdive to all four of them, and you will receive one to four Evolved DNA. Push Begin to pause the game, then select 'Ascend' to return to base. Repeat the process as many times as desired. Notice: This trick also works using the 'Case Training' option.

- Bonus assists
Successfully complete the indicated task to unlock the corresponding assist for purchase:

Countless Ammo	Successfully complete the game ten times.
Free Cross Fire	Successfully complete the game; costs 10,000 BP.
High Regen	Successfully complete the game; costs 10,000 BP.

- Unlocking cheats easily
Begin a New Game+ mode game. To unlock both cheats at no cost, unlock them using your BP, then reload the same New Game+ mode saved game without saving first. The game will resume with your original amount of BP, and the cheats will remain unlocked.

- Watch mode
Successfully complete the game to unlock Watch mode.

- Deadly mode
Successfully complete the game on the Hard difficulty to unlock the Deadly difficulty.

- Alternate shower scene
Successfully complete Mission 3. Have Aya wear a completely torn costume before the next mission where she meets the Japanese scientist. Go downstairs and turn right to enter the bathroom. Push X at the bathroom, and she will say '...', and then the shower scene will begin.