- Play as The Be victorious ink
Successfully complete Campaign mode with Magneto to unlock The Be victorious ink.

- Fourth card slot
Successfully complete Campaign mode with two different characters to unlock the fourth card slot. -From: William Fries IV

- Play as Wolverine
Successfully complete Campaign mode with Solara to unlock Wolverine. -From: William Fries IV

- Play as Venom
Successfully complete Campaign mode with Iron Man to unlock Venom. -From: William Fries IV

- Third card slot
Successfully complete Campaign mode with one character to unlock the third card slot. -From: William Fries IV

- Play as Magneto
Successfully complete Campaign mode with Venom to unlock Magneto. -From: William Fries IV

- Recharge super power faster
Keep pushed R and stand still. Do not walk or run and your super power (blue line) will refill quicker.

- Play as Solara
Successfully complete Campaign mode with Spider-Man to unlock Solara. -From: William Fries IV

- Uber cards
Successfully complete a character's Campaign mode with a gold rank in each match to unlock a 'Master Unlock' rarity card.

- Play as Captain America
Successfully complete Campaign mode with Fault Zone to unlock Captain America.

- Play as Iron Man
Successfully complete Campaign mode with Johnny Ohm to unlock Iron Man.

- Play as Spider-Man
Successfully complete Campaign mode with Brigade to unlock Spider-Man. -From: William Fries IV

- Play as Brigade
Successfully complete Campaign mode with The Thing to unlock Brigade. -From: William Fries IV