| Mini-chainsaw | Successfully complete the 'Out Of Control' mission with an 'S' rank to have Adam's small chainsaw respawn in the security room. Alternately, successfully complete 'The Shadow Of North Plaza' mission with an 'S' rank. |
| Chicago Typewriter | Successfully complete the game with an 'A' rank or better with a time under ten hours. |
| Odd Jobs mode | Successfully complete the game. |
| Mall employee uniform | Successfully complete the 'Out Of Control' mission with an 'S' rank. |
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| Apocalypse Frank costume | Overcome 53,594 zombies. |
| Arthur's Boxers | Successfully compete the game without dying. |
| White Hat | Successfully complete the game with 100% item usage. |
| Riot Gun | Successfully complete the 'Dressed For Action' mission with an 'S' rank. |
| Hockey Mask | Successfully complete 'The Cult' mission with an 'S' rank. |
| Small Mixer | Successfully complete the game to unlock it for purchase from Cletus. |
| Bikini costume | Successfully complete the game with an 'A' rank or better on the Normal difficulty. |
| Megaman Boots | Successfully complete all missions in 2nd Amendment mode. |
| Ammo Belt | Successfully complete the 'Gun Shop Standoff' mission with an 'S' rank. |
| 'The Drunkard' mission | Successfully complete the 'Out Of Control' mission with an 'S' rank. |
| New Game+ mode | Successfully complete the game. This mode allows you to begin a new game with your previously earned inventory items and level. |
| Quest mode | Successfully complete the game with an 'A' rank or better on the Normal difficulty. |
| Red 9 | Successfully complete the 'Lovers' mission with an 'S' rank. |
| Killer 7 | Successfully complete the game to get the Killer 7 instead of the repaired Blacktail from Cletus. |
| Megaman Tights | Successfully complete all missions in 2nd Amendment mode with an 'A' rank or better. |
| Pro Wrestling Briefs | Successfully complete all missions in Odd Jobs mode with an 'A' rank or better. |
| Prisoner Garb costume | Successfully complete the 'Prisoners' mission with an 'S' rank. |
| .50 caliber machine gun | Successfully complete 'The Woman Left Behind' mission with an 'S' rank. |
| Roll costume | Successfully complete the game with an 'S' rank on the Hard difficulty. |
| Turret Gun | Successfully complete the 'Prisoners' mission with an 'S' rank. |
| Laser Sword | Successfully complete all missions in Odd Jobs mode with an 'S' rank. |
| Special Forces costume | Successfully complete the game with an 'A' rank or better on the Hard difficulty. |
| Semi-Automatic Rifle | Successfully complete the 'Mark Of The Sniper' mission with an 'S' rank. |
| Real Mega Buster | Successfully complete all missions in 2nd Amendment mode with an 'S' rank. |
| Kung Fu costume | Successfully complete the game twice on the Hard difficulty. |
| Cultist Leader's Sword | Successfully complete the 'A Strange Group' mission with an 'S' rank. |
| Police Cap | Successfully complete the game with an 'A' rank or better, save all survivors, and do not allow any to escape. |
| Pro Wrestling Boots | Successfully complete Odd Jobs mode. |
| Megaman Helmet | Acquire it from the movie theater toy store. |
| 2nd Amendment mode | Successfully complete the first four missions in Quest mode. |
| School Boy Clothes | Successfully complete the game with an 'A' rank or better. |
| Bionic Commando costume | Successfully complete the game twice. |
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| Yakuza costume | Successfully complete the game with an 'A' rank or better on the Normal difficulty. |
Get an 'S' rank on all files. Near the end of Case 5, you will unlock a secret case file to take down the sniper family.
When Cletus has the Killer 7 on the table, look at it, but do not pick it up when prompted. Cletus will give it to you free later.
Once you have a sniper rifle, go to the rooftop of the mall where the elevator is located. Take a look at the parking lot through the fence at the right of the elevator door. You can see many zombies walking through the parking lot that can be shot to raise your killing score.
During the final case, when the Special Forces arrives and kills all zombies in the mall, you will see a lot of zombie corpses on the ground inside the mall, killed by the Special Forces. You can shoot them, and it counts as a kill even through they are already dead.
