Insert one of the following codes at the cheat entry screen in the options menu to obtain the corresponding effect.
There are two variations of the game; one with a black suited Spider-Man on the cover, and one without. Not all codes work in each version, and codes can vary between versions.
| Effect | Code |
| Doctor Doom; Ultimate Doctor and Professor Doom costumes | 999999 |
| Invincibility (Adventure mode only) | 100000 |
| A.I.M. Agent and Blue Suit A.I.M. Agent costume | 246246 |
| Captain America; U.S. Agent costume | 925627 or 956278 |
| No Blocking cheat | 888888 |
| Captain America; Ultimate Captain America costume | 177674 |
| Thrown Object Takedown cheat | 847936 |
| All characters | 200000 |
| Grounded cheat (hovering disabled in Battle mode) | 476863 |
| Wolverine; Brown and Feral costumes | 333333 |
| Infinite shard duration cheat | 742737 |
| Spider-Man; Symbiote Spider-Man costume | 925678 or 925628 |
| One Hit Kills cheat | 663448 |
| Silver Surfer; Anti-Surfer and Gold Surfer costumes | 555555 |
| Thor; Chain Armor and Loki-Thor's costumes | 444444 |
| Iron Man; War Machine costume | 111111 |
| The Hulk; Grey Hulk and Red Hulk costumes | 222222 |
| Super Knockback cheat | 777777 |
| Falcon; Ultimate Falcon costume | 666666 |
