Unlockables
- Dante's white-haired costume and Son of Sparda mode (stronger enemies with new attacks): complete the game on any difficulty.
- Dante's hoodless costume: complete the story on Son of Sparda difficulty.
- Dante Must Die! (more enemies, more waves and more damage): complete the game on Son of Sparda difficulty.
- Heaven or Hell (Dante and the enemies die in one hit): complete the game on Son of Sparda difficulty.
- Hell and Hell (Dante dies in one hit, the enemies have full health): complete the game on Heaven or Hell.
- Super Dante (infinite Devil Triggers, in exchange for a 50% score penalty): complete the story on Dante Must Die!
- Rare arts: use the Devil Trigger 666 times (#1), play 50 hours (#2), accumulate 5,000,000 damage (#3), complete 60 missions with an SSS rank (#4).
- "Vergil's Downfall" DLC: Hell and Hell (complete the game on Heaven or Hell) and Vergil Must Die! (complete the game on Son of Sparda).
Easy Red Orbs
- Mission 8 "Eyeless": you need a copper key for the secret mission "Taste of Heaven" (door on the right side of the long corridor that appears after using the Demon Pull on a wall; the blue branches are crossed with Eagle or Osiris and the double jump). Just before completing it, pause and restart from the checkpoint: the Red Orbs stay. You get about 2,000 Orbs in a few minutes.
- Mission 10 "Bad News" (with Heaven or Hell unlocked, where every hit kills): when Bob Barbas's health drops, jump into his eye. Shoot the enemies until Bob says "Unholy creature", then pause and restart from the checkpoint. About 1,000 kills in 15 minutes.
The 21 Hidden Keys
They are needed for the doors of the secret missions. You can't find them all on the first run: some weapons and abilities unlock later, and you can replay each mission from the menu.
- M1 (copper): after Dante's Pistol, to the left of the Lost Soul, on a suspended platform.
- M2 (copper): at the big building, stairs on the right, at the end of the corridor, in an open room. (silver): in the hole revealed by the moving corridor, break the Eryx Gem with the Eryx weapon.
- M3 (copper): near the exit door after the first battle; break with the axe the propped-up door near the checkpoint statue.
- M4: after Kat, on the right there is a painted wall: break it with Eryx and go ahead, then turn right. (gold): near the fountain square, cross the cliff with Angel Boost, use the Angel Lift to the roof and go into the black building with the cocoons.
- M5 (copper): after the Hell Knight, in the warehouse, look to the right past the barricade and go over the containers. Another key: use the Demon Pull, go left and reach the suspended platform with Angel Lift and Angel Boost.
- M6 (copper): at the start, as soon as Dante stops sliding, turn around: the key is on a ledge above the ravine.
- M7 (copper): at the second boost point, on the right, up high, behind the blue pylons (Eagle's beam). Two more: after the Egg of Rage scene, on the left with Boost and Angel Lift; and after the big Rage, at the top of the narrow corridor (copper).
- M8: after the train battle, on the right among the blue tendrils at the end of the big corridor.
- M9 (gold): in the blue room with the grate floor, on a hidden balcony: use the enemies to climb (throw an enemy in the air, double jump, repeat).
- M11 (copper): after killing the Rages, on the right after the stairs, a secret passage with a window: break the Eryx crystal on the right.
- M13 (gold): right after the club transformation, on the platform and then on the Angel Lifts up to a suspended platform.
- M15 (copper x2): during the car race, on the stacked containers on the left; and before the crash, with the Demon Pull on the bus.
- M16 (gold): on Floor 105 on the right, behind the elevator, jump between the floating crates.
- M17 (ivory): after the first battle, on the platform with the arch and tree on the right, among the blue pylons.
- M18: in the corridor to the right of Vergil, drop onto the hidden platform on the left in the ravine.
Secret Mission Doors
- 1 Aerial Brawl (copper): as soon as the boss roars and Dante says "Come back", follow a side corridor. Reward: Life Cross Fragment.
- 2 Simple Eradication: after the Demon Pull, on the left on the lower floor.
- 3 Stylish Victory: chasing the ethereal form, on the right there is a room with a Lost Soul (Angel Boost).
- 4 What Goes Around (silver): suspended platform above the square, with Lift and Angel Boost.
- 5 Simple Crossing: on the right at the crossroads, blue platform up high, then the balcony.
- 6 Delicious Conquests (silver): hunting the cameras, after the second distant blue platform.
- 7 Demonic Conflict (copper): after the first statue, floating crates at the top right.
- 8 Scattered Challenges: in the sticky tunnels, on the left, a cracked door to break with the Arbiter.
- 9 Quick Descent: before the boss arena, on the left (Angel Boost).
- 10 Divergent Massacre (gold): on the upside-down gray building, with Lift and Angel Boost.
- 11 Angelic War: after the elevator, pass the floor with the Eryx.
- 12 Taste of Heaven: after the Demon Pull, jump to the left, pass the cracked wall and then the blue pylons with Eagle.
- 13 Moderate Crossing: in the upside-down corridor with black waste, open gate at the top left and cracked door.
- 14 Subsistence: in the big room with dangling metal platforms. Reward: Devil Trigger Cross Fragment.
- 15 The Power Within: after the "You can't hide" door, on the right, beyond the red barrier.
- 16 Shenanigan (ivory): in the club's Limbo, behind the statue and on the raised platform.
- 17 Quick Acquisitions: after the Dream Chaser assault at the green statue, a platform lower down.
- 18 Extreme Crossing: Floor 106, go down the stairs instead of up.
- 19 Lure and Swap: Floor 154, after the bridge toward the tower elevator.
- 20 A Day in Hell: early, after the first statue, two Angel Lifts and Boost toward the Demon Pull.
- 21 Colossal Triumph: corridor near Vergil, before the Generator chamber.
Easy Achievements
- A man with courage and honor (M6): reach the bottom of the descent within 2 minutes, killing all 10 enemies and opening the door (better on Human).
- Every hero has a weakness (M17): avoid the fire that comes out of the ground every 7 seconds; it damages you only in the air.
- It's just the rain (M1): lure the 10 enemies under the hurricane and throw them in the air with B.
- Look at how lucky your day is (M3, Human): defeat the two waves and the Ravager without being hit; then Angel Boost over the lagoons. M15 is very short: clear the path for the car and ignore the enemies.
- Now my coat is all singed (M16): in the corridor with the lasers vary your jump and use hover (LT + A); from the ground for the low barriers.
- Sensational (M11, Human): Arbiter Quake (RT B), Osiris Karma (LT Y), then Eagle for SSS rank.
